组氨酸解氨酶

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组氨酸解氨酶
标识
代号 HAL; HIS; HSTD
扩展标识 遗传学609457 鼠基因96010 同源基因68229 GeneCards: HAL Gene
EC编号 4.3.1.3
直系同源体
物种 人类 鼠类
Entrez 3034 15109
Ensembl ENSG00000084110 ENSMUSG00000020017
UniProt P42357 P35492
mRNA序列 NM_002108 NM_010401.3
蛋白序列 NP_002099 NP_034531.1
基因位置 Chr 12:
96.37 – 96.39 Mb
Chr 10:
92.95 – 92.98 Mb
PubMed查询 [1] [2]
组氨酸解氨酶
识别码
EC编号 4.3.1.3
CAS号 9013-75-6
数据库
IntEnz IntEnz浏览
BRENDA BRENDA入口
ExPASy NiceZyme浏览
KEGG KEGG入口
MetaCyc 代谢路径
PRIAM 概述
PDB RCSB PDB PDBe PDBsum
基因本体 AmiGO / EGO

组氨酸解氨酶英语:Histidine ammonia-lyase,或称为组氨酸氨裂解酶组氨酸)在人体中是一种由HAL基因编码的酶[1][2]。组氨酸解氨酶将组氨酸转变为氨与尿刊酸

目录

功能

组氨酸解氨酶是一种胞质溶胶酶,催化组氨酸代谢过程中的第一步,即L-组氨酸的非氧化脱氨形成反式尿刊酸[1]

病理学

编码组氨酸酶的基因的突变组氨酸血症尿刊酸尿症两者有关。

深入阅读

  • Suchi M, Harada N, Wada Y, Takagi Y. Molecular cloning of a cDNA encoding human histidase.. Biochim. Biophys. Acta. 1993, 1216 (2): 293–5. PMID 7916645. 
  • Davila S, Froeling FE, Tan A, et al.. New genetic associations detected in a host response study to hepatitis B vaccine.. Genes Immun.. 2010, 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496. 
  • Gerhard DS, Wagner L, Feingold EA, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/ The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).]. Genome Res.. 2004, 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. PMC 528928. 
  • Eckhart L, Schmidt M, Mildner M, et al.. Histidase expression in human epidermal keratinocytes: regulation by differentiation status and all-trans retinoic acid.. J. Dermatol. Sci.. 2008, 50 (3): 209–15. doi:10.1016/j.jdermsci.2007.12.009. PMID 18280705. 
  • Welsh MM, Karagas MR, Applebaum KM, et al.. A role for ultraviolet radiation immunosuppression in non-melanoma skin cancer as evidenced by gene-environment interactions.. Carcinogenesis. 2008, 29 (10): 1950–4. doi:10.1093/carcin/bgn160. PMID 18641401. 
  • Strausberg RL, Feingold EA, Grouse LH, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/ Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.]. Proc. Natl. Acad. Sci. U.S.A.. 2002, 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. PMC 139241. 
  • Kawai Y, Moriyama A, Asai K, et al.. Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene.. Hum. Genet.. 2005, 116 (5): 340–6. doi:10.1007/s00439-004-1232-5. PMID 15806399. 
  • Taylor RG, Garcí­a-Heras J, Sadler SJ, et al.. Localization of histidase to human chromosome region 12q22----q24.1 and mouse chromosome region 10C2----D1.. Cytogenet. Cell Genet.. 1991, 56 (3-4): 178–81. PMID 2055114. 
  • Alemán G, Ortí­z V, Langley E, et al.. Regulation by glucagon of the rat histidase gene promoter in cultured rat hepatocytes and human hepatoblastoma cells.. Am. J. Physiol. Endocrinol. Metab.. 2005, 289 (1): E172-9. doi:10.1152/ajpendo.00584.2004. PMID 15741241. 

参考文献

  1. 1.0 1.1 Entrez Gene: histidine ammonia-lyase. 
  2. Suchi M, Sano H, Mizuno H, Wada Y. Molecular cloning and structural characterization of the human histidase gene (HAL). Genomics. September 1995, 29 (1): 98–104. doi:10.1006/geno.1995.1219. PMID 8530107. 

外部链接


组氨酸解氨酶引用了美国国家医学图书馆提供的资料,这些资料属于公共领域。

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