视网膜母细胞瘤蛋白

(重定向自RB1
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Retinoblastoma 1

PDB rendering based on 1ad6.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 RB1; OSRC; RB; p105-Rb; pRb; pp110
扩展标识 遗传学614041 鼠基因97874 同源基因272 ChEMBL: 5288 GeneCards: RB1 Gene
RNA表达模式
PBB GE RB1 203132 at.png
PBB GE RB1 211540 s at.png
更多表达数据
直系同源体
物种 人类 鼠类
Entrez 5925 19645
Ensembl ENSG00000139687 ENSMUSG00000022105
UniProt P06400 P13405
mRNA序列 NM_000321 NM_009029
蛋白序列 NP_000312 NP_033055
基因位置 Chr 13:
48.88 – 49.06 Mb
Chr 14:
73.18 – 73.33 Mb
PubMed查询 [1] [2]

视网膜母细胞瘤蛋白英语:retinoblastoma protein,常缩写为pRbRBRB1)又译为视网膜细胞瘤蛋白是一种抑癌蛋白,并在几种主要的癌症发生时失活[1]。pRb的功能之一是通过抑制细胞周期进程直到细胞准备妥当来防止细胞过度生长。

pRb是袋状蛋白家族的一员,其特点是有一个口袋状的结构用以结合其它蛋白[2][3]。使得一些致癌变蛋白,比如高危险群人类乳突病毒感染的细胞产生的蛋白,结合并抑制pRb,最终导致癌症。

目录

相互作用

已知Rb蛋白与下列蛋白质相互作用关系:

细胞凋亡中涉及的信号通路一览

参考文献

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视网膜母细胞瘤蛋白引用了美国国家医学图书馆提供的资料,这些资料属于公共领域。


延伸阅读

  • Momand J, Wu HH, Dasgupta G. MDM2-master regulator of the p53 tumor suppressor protein. Gene. 2000, 242 (1–2): 15–29. doi:10.1016/S0378-1119(99)00487-4. PMID 10721693. 
  • Zheng L, Lee WH. Retinoblastoma tumor suppressor and genome stability. Adv. Cancer Res.. Advances in Cancer Research. 2003, 85: 13–50. doi:10.1016/S0065-230X(02)85002-3. ISBN 978-0-12-006685-8. PMID 12374284. 
  • Classon M, Harlow E. The retinoblastoma tumour suppressor in development and cancer. Nature Reviews Cancer. 2003, 2 (12): 910–7. doi:10.1038/nrc950. PMID 12459729. 
  • Lai H, Ma F, Lai S. Identification of the novel role of pRB in eye cancer. J. Cell. Biochem.. 2003, 88 (1): 121–7. doi:10.1002/jcb.10283. PMID 12461781. 
  • Simin K, Wu H, Lu L, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC340938/ pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent Epithelia]. PLoS Biol.. 2006, 2 (2): E22. doi:10.1371/journal.pbio.0020022. PMID 14966529. PMC 340938. 
  • Lohmann DR, Gallie BL. Retinoblastoma: revisiting the model prototype of inherited cancer. American Journal of Medical Genetics. 2004, 129 (1): 23–8. doi:10.1002/ajmg.c.30024. PMID 15264269. 
  • Clemo NK, Arhel NJ, Barnes JD, et al.. The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival. Biochem. Soc. Trans.. 2005, 33 (Pt 4): 676–8. doi:10.1042/BST0330676. PMID 16042572. 
  • Rodríguez-Cruz M, del Prado M, Salcedo M. [Genomic retinoblastoma perspectives: implications of tumor supressor gene RB1]. Rev. Invest. Clin.. 2006, 57 (4): 572–81. PMID 16315642. 
  • Knudsen ES, Knudsen KE. Retinoblastoma tumor suppressor: where cancer meets the cell cycle. Exp. Biol. Med. (Maywood). 2006, 231 (7): 1271–81. PMID 16816134. 

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