表皮生长因子受体

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Epidermal growth factor receptor
表皮生长因子受体

表皮生长因子受体的胞外结构域与表皮生长因子结合的复合体,引自PDB1nql[1]
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 EGFR; ERBB; ERBB1; HER1; PIG61; mENA
扩展标识 遗传学131550 鼠基因95294 同源基因74545 ChEMBL: 203 GeneCards: EGFR Gene
EC编号 2.7.10.1
RNA表达模式
PBB GE EGFR 201983 s at.png
更多表达数据
直系同源体
物种 人类 鼠类
Entrez 1956 13649
Ensembl ENSG00000146648 ENSMUSG00000020122
UniProt P00533 Q01279
mRNA序列 NM_005228 NM_007912
蛋白序列 NP_005219 NP_031938
基因位置 Chr 7:
55.09 – 55.32 Mb
Chr 11:
16.75 – 16.92 Mb
PubMed查询 [1] [2]

表皮生长因子受体英语:epidermal growth factor receptor,简称为EGFRErbB-1HER1)是一类名为表皮生长因子家族(EGF-家族)的细胞蛋白配体细胞表面受体[2]

表皮生长因子受体是ErbB受体家族家族的成员之一,ErbB家族是包含四种紧密联系蛋白的亚家族,这四种蛋白分别是受体酪氨酸激酶类:EGFR(ErbB-1)HER2/c-neu(ErbB-2)、Her 3(ErbB-3)以及Her 4(ErbB-4)。影响EGFR表达或活性的突变可能导致癌症[3]

表皮生长因子及其受体是由范德堡大学的斯坦利·科恩发现的,科恩与丽塔·列维-蒙塔尔奇尼因发现生长因子类而共同获得了1986年诺贝尔生理学或医学奖

目录

功能

EGFR信号传导级联

表皮生长因子受体(EGFR)存在于细胞表面且因结合特异性受体而被激活,这些受体包括表皮生长因子和TGFα。ErbB2并无已知的直接激活配体,可能结构性地处于激活状态,或在与如EGFR等其他家族成员形成异源二聚体时被激活。

参考文献

  1. PMID 12620237PubMed
    本引用来源将会在数十分钟后自动完成。您可以检查英文对应模板手动扩充
  2. Herbst RS. Review of epidermal growth factor receptor biology. Int. J. Radiat. Oncol. Biol. Phys.. 2004, 59 (2 Suppl): 21–6. doi:10.1016/j.ijrobp.2003.11.041. PMID 15142631. 
  3. Zhang H, Berezov A, Wang Q, Zhang G, Drebin J, Murali R, Greene MI. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1934579/ ErbB receptors: from oncogenes to targeted cancer therapies]. J. Clin. Invest.. August 2007, 117 (8): 2051–8. doi:10.1172/JCI32278. PMID 17671639. PMC 1934579. 

深入阅读

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  • Carpenter G. The EGF receptor: a nexus for trafficking and signaling. BioEssays. 2000, 22 (8): 697–707. doi:10.1002/1521-1878(200008)22:8<697::AID-BIES3>3.0.CO;2-1. PMID 10918300. 
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  • Reiter JL, Maihle NJ. Characterization and expression of novel 60-kDa and 110-kDa EGFR isoforms in human placenta. Annals of the New York Academy of Sciences. 2003, 995 (1): 39–47. doi:10.1111/j.1749-6632.2003.tb03208.x. PMID 12814937. 
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