钙调磷酸酶

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蛋白磷酸酶3,催化亚基,α同工酶

PDB rendering based on 1aui.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 PPP3CA; CALN; CALNA; CALNA1; CCN1; CNA1; PPP2B
扩展标识 遗传学114105 鼠基因107164 同源基因55497 GeneCards: PPP3CA Gene
EC编号 3.1.3.16
RNA表达模式
PBB GE PPP3CA 202429 s at tn.png
PBB GE PPP3CA 202425 x at tn.png
PBB GE PPP3CA 202457 s at tn.png
更多表达数据
直系同源体
物种 人类 鼠类
Entrez 5530 19055
Ensembl ENSG00000138814 ENSMUSG00000028161
UniProt Q08209 P63328
mRNA序列 NM_000944.4 NM_008913.4
蛋白序列 NP_000935.1 NP_032939.1
基因位置 Chr 4:
101.94 – 102.27 Mb
Chr 3:
136.33 – 136.6 Mb
PubMed查询 [2] [3]

钙调磷酸酶[1]英语:Calcineurin,亦称为蛋白磷酸酶3或蛋白磷酸酶2B,分别简称为PPP3CAPP2B)其在体内的作用为启动T细胞并可以通过药物来阻断这一过程。

钙调磷酸酶为很多种免疫抑制药的作用对象如,环孢霉素,吡美莫司他克莫司

目录

参考文献

深入阅读


  • Crabtree GR. Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT. Cell. 1999, 96 (5): 611–4. doi:10.1016/S0092-8674(00)80571-1. PMID 10089876. 
  • Giri PR, Higuchi S, Kincaid RL. Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit. Biochem. Biophys. Res. Commun.. 1992, 181 (1): 252–8. doi:10.1016/S0006-291X(05)81410-X. PMID 1659808. 
  • Kincaid RL, Giri PR, Higuchi S, et al.. Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods. J. Biol. Chem.. 1990, 265 (19): 11312–9. PMID 2162844. 
  • Guerini D, Klee CB. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC298458/ Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain]. Proc. Natl. Acad. Sci. U.S.A.. 1990, 86 (23): 9183–7. doi:10.1073/pnas.86.23.9183. PMID 2556704. PMC 298458. 
  • Kincaid RL, Nightingale MS, Martin BM. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC282646/ Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin]. Proc. Natl. Acad. Sci. U.S.A.. 1988, 85 (23): 8983–7. doi:10.1073/pnas.85.23.8983. PMID 2848250. PMC 282646. 
  • Coghlan VM, Perrino BA, Howard M, et al.. Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. Science. 1995, 267 (5194): 108–11. doi:10.1126/science.7528941. PMID 7528941. 
  • Griffith JP, Kim JL, Kim EE, et al.. X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex. Cell. 1995, 82 (3): 507–22. doi:10.1016/0092-8674(95)90439-5. PMID 7543369. 
  • Shibasaki F, McKeon F. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC2120616/ Calcineurin functions in Ca(2+)-activated cell death in mammalian cells]. J. Cell Biol.. 1995, 131 (3): 735–43. doi:10.1083/jcb.131.3.735. PMID 7593193. PMC 2120616. 
  • Muramatsu T, Kincaid RL. Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha). Biochim. Biophys. Acta. 1993, 1178 (1): 117–20. doi:10.1016/0167-4889(93)90117-8. PMID 8392375. 
  • Cameron AM, Steiner JP, Roskams AJ, et al.. Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux. Cell. 1996, 83 (3): 463–72. doi:10.1016/0092-8674(95)90124-8. PMID 8521476. 
  • Kissinger CR, Parge HE, Knighton DR, et al.. Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. Nature. 1996, 378 (6557): 641–4. doi:10.1038/378641a0. PMID 8524402. 
  • Wang MG, Yi H, Guerini D, et al.. Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively. Cytogenet. Cell Genet.. 1997, 72 (2-3): 236–41. doi:10.1159/000134198. PMID 8978785. 
  • Shibasaki F, Kondo E, Akagi T, McKeon F. Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2. Nature. 1997, 386 (6626): 728–31. doi:10.1038/386728a0. PMID 9109491. 
  • Kashishian A, Howard M, Loh C, et al.. AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region. J. Biol. Chem.. 1998, 273 (42): 27412–9. doi:10.1074/jbc.273.42.27412. PMID 9765270. 
  • Wang HG, Pathan N, Ethell IM, et al.. Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science. 1999, 284 (5412): 339–43. doi:10.1126/science.284.5412.339. PMID 10195903. 
  • Fuentes JJ, Genescà L, Kingsbury TJ, et al.. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum. Mol. Genet.. 2000, 9 (11): 1681–90. doi:10.1093/hmg/9.11.1681. PMID 10861295. 
  • Hartley JL, Temple GF, Brasch MA. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC310948/ DNA cloning using in vitro site-specific recombination]. Genome Res.. 2001, 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863. PMC 310948. 
  • Frey N, Richardson JA, Olson EN. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC18970/ Calsarcins, a novel family of sarcomeric calcineurin-binding proteins]. Proc. Natl. Acad. Sci. U.S.A.. 2001, 97 (26): 14632–7. doi:10.1073/pnas.260501097. PMID 11114196. PMC 18970. 
  • Siddiq A, Miyazaki T, Takagishi Y, et al.. Expression of ZAKI-4 messenger ribonucleic acid in the brain during rat development and the effect of hypothyroidism. Endocrinology. 2001, 142 (5): 1752–9. doi:10.1210/en.142.5.1752. PMID 11316738. 

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