葡萄糖-6-磷酸脱氢酶

葡萄糖-6-磷酸脱氢酶
	葡萄糖-6-磷酸脱氢酶结构（PDB 1qki）
命名
系统命名	D-glucose-6-phosphate:NADP+ 1-oxidoreductase
缩写	G6PDH; GPD
别名	NADP-glucose-6-phosphate dehydrogenase; Zwischenferment; D-glucose 6-phosphate dehydrogenase; glucose 6-phosphate dehydrogenase (NADP); NADP-dependent glucose 6-phosphate dehydrogenase; 6-phosphoglucose dehydrogenase; Entner-Doudoroff enzyme; glucose-6-phosphate 1-dehydrogenase
识别码
EC编号	1.1.1.49
CAS号	9001-40-5
数据库
IntEnz	IntEnz浏览
BRENDA	BRENDA入口
ExPASy	NiceZyme浏览
KEGG	KEGG入口
MetaCyc	代谢路径
PRIAM	概述
PDB	RCSB PDB PDBe PDBsum
基因本体	AmiGO / EGO
搜索
PMC	相关文献
PubMed	相关文献

葡萄糖-6-磷酸脱氢酶
	; PDB rendering based on 1qki.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1QKI, 2BH9, 2BHL
标识
代号	G6PD; G6PD1
扩展标识	遗传学：305900 鼠基因：105979 同源基因：37906 GeneCards: G6PD Gene
EC编号	1.1.1.49
基因本体论描述
分子功能	· glucose-6-phosphate dehydrogenase activity; · binding; · glucose binding; · glucose binding; · oxidoreductase activity; · protein homodimerization activity; · NADP binding;
细胞成分	· cytoplasm; · centrosome; · cytosol; · cytosol; · internal side of plasma membrane; · intracellular membrane-bounded organelle;
生物过程	· cytokine production; · carbohydrate metabolic process; · pentose-phosphate shunt; · pentose-phosphate shunt; · lipid metabolic process; · cholesterol biosynthetic process; · NADPH regeneration; · glutathione metabolic process; · pentose-phosphate shunt, oxidative branch; · negative regulation of protein glutathionylation; · pentose biosynthetic process; · cellular response to oxidative stress; · erythrocyte maturation; · ribose phosphate biosynthetic process; · glucose 6-phosphate metabolic process; · oxidation-reduction process;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
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A+医学百科 >> 葡萄糖-6-磷酸脱氢酶

葡萄糖-6-磷酸脱氢酶（英语：glucose-6-phosphate dehydrogenase，EC 1.1.1.49）是一种以NAD⁺或NADP⁺为受体、作用于供体 CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应：

葡萄糖-6-磷酸脱氢酶主要参与磷酸戊糖途径，也能缓慢地作用在β-D-葡萄糖等其他糖类上。这种酶可由其底物葡萄糖-6-磷酸激活，如果人类表达葡萄糖-6-磷酸脱氢酶的基因 G6PD有缺陷，将会导致葡萄糖-6-磷酸脱氢酶缺乏症，引发非免疫性溶血性贫血。葡萄糖-6-磷酸脱氢酶存在于众多生物细胞内，高等植物拥有数种葡萄糖-6-磷酸脱氢酶的蛋白异构体（protein isoform），它们分布于细胞质基质、和过氧化物酶体等细胞结构中。^[1]

参考文献

↑ Corpas FJ et al.. A dehydrogenase-mediated recycling system of NADPH in plant peroxisomes. Biochem. J.. 1998, 330 (7): 777–784.

Vulliamy T, Beutler E, Luzzatto L. Variants of glucose-6-phosphate dehydrogenase are due to missense mutations spread throughout the coding region of the gene.. Hum. Mutat.. 1993, 2 (3): 159–67. doi:10.1002/humu.1380020302. PMID 8364584.
Mason PJ. New insights into G6PD deficiency.. Br. J. Haematol.. 1996, 94 (4): 585–91. PMID 8826878.
Wajcman H, Galactéros F. [Glucose 6-phosphate dehydrogenase deficiency: a protection against malaria and a risk for hemolytic accidents]. C. R. Biol.. 2004, 327 (8): 711–20. PMID 15506519.