| ApoC-I |
 |
| structural studies of a baboon (papio sp.) plasma protein inhibitor of cholesteryl ester transferase. |
| 鉴定 |
| 标志 |
ApoC-I |
| Pfam（蛋白家族查询站） |
PF04691 |
| InterPro（蛋白数据整合站） |
IPR006781 |
| SCOP（蛋白结构分类数据站） |
1ale |
|
|
载脂蛋白C1（英语：Apolipoprotein C-I）是一个由人类基因 APOC1 编码的脂蛋白[1][2]。
功能
该基因编码的蛋白质是载脂蛋白C家族中的一员。
参考文献
- ↑ Tata F, Henry I, Markham AF, Wallis SC, Weil D, Grzeschik KH, Junien C, Williamson R, Humphries SE. Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19. Hum. Genet.. 1985, 69 (4): 345–9. doi:10.1007/BF00291654. PMID 2985493.
- ↑ Smit M, van der Kooij-Meijs E, Frants RR, Havekes L, Klasen EC. Apolipoprotein gene cluster on chromosome 19. Definite localization of the APOC2 gene and the polymorphic Hpa I site associated with type III hyperlipoproteinemia. Hum. Genet.. January 1988, 78 (1): 90–3. doi:10.1007/BF00291243. PMID 2892779.
进一步阅读
- Shulman RS, Herbert PN, Wehrly K, Fredrickson DS. Thf complete amino acid sequence of C-I (apoLp-Ser), an apolipoprotein from human very low density lipoproteins. J. Biol. Chem.. 1975, 250 (1): 182–90. PMID 166984.
- Lauer SJ, Walker D, Elshourbagy NA, et al.. Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene. J. Biol. Chem.. 1988, 263 (15): 7277–86. PMID 2835369.
- Smit M, van der Kooij-Meijs E, Woudt LP, et al.. Exact localization of the familial dysbetalipoproteinemia associated HpaI restriction site in the promoter region of the APOC1 gene. Biochem. Biophys. Res. Commun.. 1988, 152 (3): 1282–8. doi:10.1016/S0006-291X(88)80424-8. PMID 2897845.
- Davison PJ, Norton P, Wallis SC, et al.. There are two gene sequences for human apolipoprotein CI (apo CI) on chromosome 19, one of which is 4 kb from the gene for apo E. Biochem. Biophys. Res. Commun.. 1986, 136 (3): 876–84. doi:10.1016/0006-291X(86)90414-6. PMID 3013172.
- Myklebost O, Rogne S. The gene for human apolipoprotein CI is located 4.3 kilobases away from the apolipoprotein E gene on chromosome 19. Hum. Genet.. 1986, 73 (4): 286–9. doi:10.1007/BF00279087. PMID 3017837.
- Jackson RL, Sparrow JT, Baker HN, et al.. The primary structure of apolopoprotein-serine. J. Biol. Chem.. 1974, 249 (16): 5308–13. PMID 4369340.
- Knott TJ, Robertson ME, Priestley LM, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC318798/ Characterisation of mRNAs encoding the precursor for human apolipoprotein CI]. Nucleic Acids Res.. 1984, 12 (9): 3909–15. doi:10.1093/nar/12.9.3909. PMID 6328444. PMC 318798.
- Servillo L, Brewer HB, Osborne JC. Evaluation of the mixed interaction between apolipoproteins A-II and C-I equilibrium sedimentation. Biophys. Chem.. 1981, 13 (1): 29–38. doi:10.1016/0301-4622(81)80022-1. PMID 6789904.
- Curry MD, McConathy WJ, Fesmire JD, Alaupovic P. Quantitative determination of apolipoproteins C-I and C-II in human plasma by separate electroimmunoassays. Clin. Chem.. 1981, 27 (4): 543–8. PMID 7471419.
- Rozek A, Buchko GW, Cushley RJ. Conformation of two peptides corresponding to human apolipoprotein C-I residues 7-24 and 35-53 in the presence of sodium dodecyl sulfate by CD and NMR spectroscopy. Biochemistry. 1995, 34 (22): 7401–8. doi:10.1021/bi00022a013. PMID 7779782.
- Maruyama K, Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene. 1994, 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Trask B, Fertitta A, Christensen M, et al.. Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers. Genomics. 1993, 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525.
- Kamino K, Yoshiiwa A, Nishiwaki Y, et al.. Genetic association study between senile dementia of Alzheimer's type and APOE/C1/C2 gene cluster. Gerontology. 1996, 42 Suppl 1: 12–9. doi:10.1159/000213820. PMID 8804993.
- Rozek A, Buchko GW, Kanda P, Cushley RJ. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC2143781/ Conformational studies of the N-terminal lipid-associating domain of human apolipoprotein C-I by CD and 1H NMR spectroscopy]. Protein Sci.. 1998, 6 (9): 1858–68. doi:10.1002/pro.5560060906. PMID 9300485. PMC 2143781.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al.. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. Gene. 1997, 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Halushka MK, Fan JB, Bentley K, et al.. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat. Genet.. 1999, 22 (3): 239–47. doi:10.1038/10297. PMID 10391210.
- Freitas EM, Zhang WJ, Lalonde JP, et al.. Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1. DNA Seq.. 1999, 9 (2): 89–100. doi:10.3109/10425179809086433. PMID 10520737.
- Gautier T, Masson D, de Barros JP, et al.. Human apolipoprotein C-I accounts for the ability of plasma high density lipoproteins to inhibit the cholesteryl ester transfer protein activity. J. Biol. Chem.. 2001, 275 (48): 37504–9. doi:10.1074/jbc.M007210200. PMID 10978346.
- Hartley JL, Temple GF, Brasch MA. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC310948/ DNA cloning using in vitro site-specific recombination]. Genome Res.. 2001, 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863. PMC 310948.
参考来源
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